| Akshay Kumar | DCP Veer "Surya" Sooryavanshi IPS, ATS Chief |
| Katrina Kaif | Dr. Ria Sooryavanshi, Surya's wife |
| Ajay Devgn | DCP Bajirao Singham IPS |
| Ranveer Singh | Inspector Sangram "Simmba" Bhalerao |
| Jaaved Jaaferi | Joint CP Kabir Shroff IPS, Surya's senior officer |
| Jackie Shroff | Omar Hafeez, Lashkar chief and a terrorist |
| Vivan Bhatena | Senior Inspector Vivaan Singh |
| Niharica Raizada | Inspector Tara Manchandani |
| Gulshan Grover | Maulana Kader Usmani, Bilal's partner |
| Abhimanyu Singh | Riyaaz Hafeez, Omar's son / Rajbir Rathod |
| Nikitin Dheer | Mukhtar Ansari / Vivek Shastri |
| Sikandar Kher | John Mascarenhas, a taxi driver in Goa |
| Kumud Mishra | Bilal Ahmed, Omar's partner / Ajay Gupta |
| Mrunal Jain | Raza Hafeez |
| Rajendra Gupta | Naeem Khan, Abbas's father and a former policeman |
| Asif Basra | Rafique Siddiqui, Kader's aide |
| Shruti Panwar | Mafeeza Hafeez, Omar's wife |
| Uday Tikekar | Chief Minister of Maharashtra |
| Anil Charanjeett | Aatmaram, Sawantwadi man (special appearance) |
| Ajit Shidhaye | Murad Ahmed |
| Ashish Warang | Ashish Tambe, Surya's fellow officer |
| Umakant Patil | Sub Inspector Umakant Bhide, Surya's fellow officer |
| Meenal Sahu | Jyoti Gupta, Rajbir's wife |
| Sukanya Dhanda | Zahida Usmani, Kader's wife |
| Raaj Gopal Iyer | Manish Rao |
| Amrit Pal Singh | Inspector Abbas Naeem Khan, Surya's fellow officer & Naeem Khan's Son |
| Sofiya Khan | Lily Dias, John's girlfriend |
| Vidhaan Sharma | Aryan Sooryavanshi, Surya & Ria's son |
| Anuva Gupta | Sneha Bose, Ria's colleague |
| Tawhid Rike Zaman | Ria's friend |
| Krishna Kotian | ATS Officer |
| Anil Khopkar | Maulana |
| Sharvari Lohakare | Tai |
| Siddhartha Jadhav | Sub-Inspector Santosh Tawde, Simmba's fellow officer (special appearance) |
